Early Detection of Hypoglycaemia in Type 1 Diabetes (T1D) via Graphene-Based Wearable Electronic Textiles
UWE funded project
Nazmul Karim, Associate Professor – CFPR, UWE
Aniko Varadi, Professor and Director – CRIB, UWE
Alex Yue, Senior Lecturer (Bio-Instrumentation) – FET, UWE
The project aims to develop wearable, flexible and machine washable electronic textiles that can continuously detect low glucose levels (i.e. hypoglycaemia) in people with diabetes via electrocardiogram (ECG) signals in a non-invasive way. Early detection of hypoglycaemia is essential as it could lead to a medical emergency such as coma or death.
Highly conductive graphene-based inks will be developed and printed onto textiles. For heart monitoring, the printed graphene textiles will then be attached to human body and a ECG recording unit. The recorded heart rate data will be transferred to a mobile applications software via Bluetooth in a non-invasive way. It will then be compared with standard ECG device to enable a robust, reliable and truly wearable ECG device based on graphene e-textiles.
Usually finger stick glucose measurement is used for hypoglycaemia. Glucose levels below 70 mg/dL and 54 mg/dL are categorized as mild and serious hypoglycaemia. Heart rate variability (HRV) measurement could be useful for real-time early detection of hypoglycaemia, as the sympathetic nervous system is stimulated by hypoglycaemia. In this study, HRV of a group of type 2 diabetes patients will be monitored continuously using a robust, reliable and comfortable graphene-based ECG textile. At the same time glucose levels will be monitored via finger stick method in order to correlate hypoglycaemia event with HRV.